By John G. Bartlett

ISBN-10: 0781738962

ISBN-13: 9780781738965

Designed to supply easy access to the factors with which to struggle infectious illness via targeting choice, right doses, expenditures, and unwanted effects of antimicrobial brokers, the 2004 notebook of Infectious sickness remedy attracts broadly from options made by means of the facilities for illness keep an eye on, the clinical Letter, the yank clinic Formulary carrier, and the AMA's Drug reviews. Tabular fabric has been up-to-date to incorporate all newly authorized antibiotics, in addition to new suggestions for administration.

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Difficile colitis, reversible dose-related hearing loss and cefixime); pain at IM injection sites (less with cefazolin) Cidofovir Nephropathy—dose dependent: Reduce with IV hydration and probenecid; monitor creatinine and urinalysis. Report renal failure to Gilead: 800-GILEAD-5 or the FDA: 800-FDA-1088. Probenecid: Chills, fever, headache, rash, nausea in 30–50% Ciprofloxacin (Cipro) See quinolones Clarithromycin (Biaxin) Rash, C. difficile colitis, GI intolerance (oral) Blood dyscrasias, hepatic damage, neutropenia, neuromuscular blockade, eosinophilia, fever, metallic taste, phlebitis at IV infusion sites, esophageal ulceration CNS—anxiety, confusion, depression, somnolence, disorientation, headache, hallucinations, tremor, hyper-reflexia, increased CSF protein, and pressure (dose related and reversible) (contraindicated in active alcoholics; twitching and seizures prevented with large doses of pyridoxine—100 mg tid) Liver damage, malabsorption, peripheral neuropathy, folate deficiency, anemia Coma, seizures (contraindicated in epileptics), hypersensitivity reactions, heart failure, arrhythmias Rash, fever, nausea, anorexia, neutropenia—sufficiently severe to require discontinuation in 30–40% of HIV infected patients Blood dyscrasias (methemogloblinemia and sulfahemoglobinemia ± G6PD deficiency)—warn patient to observe for cyanosis and dark urine; nephrotic syndrome; blurred vision; photosensitivity, tinnitis; insomnia; irritability; headache (transient) Hypoalbuminemia, epidermal necrolysis, optic atrophy, agranulocytosis, peripheral neuropathy, aplastic anemia, “sulfone syndrome” (fever, exfoliative dermatitis, jaundice, adenopathy, methemo-globinemia, and anemia—treat with steroids), renal papillary necrosis Dose related elevated CPK with or without symptoms or myopathy (reversible) Elevated transaminases; neuropathy Clindamycin (Cleocin) Diarrhea (frequency of C.

Initial dose is not modified in renal failure. 3. Adjustments in subsequent doses for renally excreted drugs may be accomplished by a) giving the usual maintenance dose at extended intervals, usually three half-lives (extended interval method); b) giving reduced doses at the usual intervals (dose reduction method); or c) a combination of each. 85 Pitfalls and notations with calculations follow. a. Elderly patient: Serum creatinine may be deceptively low (with danger of overdosing) because of reduced muscle mass.

Nausea, vomiting Histamine-mediated adverse drug reaction with rash, face swelling, pruritis; fever; increased alkaline phosphotase; hypokalemia; proteinuria Ceftibutin — GI intolerance—4%, headache, diarrhea, rash pruritis; 2% in clinical trial discontinued drug due to ADR C. difficile -associated diarrhea, colitis Cephalosporins Phlebitis at infusion sites; diarrhea (especially cefoperazone Allergic reactions (anaphylaxis rare), diarrhea and C. difficile colitis, hypoprothrombinemia (cefamandole, cefoperazone, moxalactam), platelet dysfunction Hemolytic anemia, interstitial nephritis (cephalothin), hepatic (moxalactam), eosinophilia, positive Coombs' test Serum sickness (especially prolonged parenteral use of cefaclor), cholelithiasis (ceftriaxone) dysfunction, convulsions (high dose with renal failure), neutropenia, thrombocytopenia, confusion, disorientation, hallucinations Chloramphenicol (Chloromycetin) GI intolerance (oral), marrow suppression (dose related) Fatal aplastic anemia (1:40,000), fever, allergic reactions, peripheral neuropathy, optic neuritis, C.

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2004 Pocket Book of Infectious Disease Therapy by John G. Bartlett

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