By Eric Guaguere, Pascal Prelaud, D.W. Scott, M. Craig

A realistic advisor to tom cat Dermatology

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Extra info for A Practical guide to Feline Dermatology

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There is strong evidence that cholesterol interacts with phospholipids to form oneto-one molar complexes involving hydrogen bonding of the 3-␤-hydroxyl of cholesterol with the glyceryl oxygen at the 2 position of the phospholipid (101). It is possible that a similar type of binding occurs between ceramides and cholesterol within skin lipids. The exact functions of cholesterol esters within the stratum corneum lamellae are also elusive. It is theoretically possible that cholesterol esters may span adjacent bilayers and serve as additional stabilizing moieties.

1992) Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest 89:530–538. Elias PM, Feingold KR. (1992) Lipids and the epidermal water barrier: metabolism, regulation, and pathophysiology. Semin Dermatol 11:176–182. Imokawa G. (1980) Comparative study on the mechanism of irritation by sulfate and phosphate type of anionic surfactants. J Soc Cosmet Chem 31:45–66. Patil SM, Singh P, Maibach HI. (1994) Cumulative irritancy in man to sodium lauryl sulfate: the overlap phenomenon.

Science 215:1239–1241. Borradori L, Sonnenberg A. (1999) Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol 112:411–418. Sawamura D, Li K, Chu M–L, Uitto J. (1991) Human bullous pemphigoid antigen (BPAG1): amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains. J Biol Chem 266:17784–17790. Li K, Tamai K, Tan EML, Uitto J. (1993) Cloning of type XVII collagen. Complementary and genomic DNA sequences of mouse 180-kDa bullous pemphigoid antigen (BPAG2) predict an interrupted collagenous domain, a transmembrane segment, and unusual features in the 5Ј-end of the gene and the 3Ј-untranslated region of mRNA.

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A Practical guide to Feline Dermatology by Eric Guaguere, Pascal Prelaud, D.W. Scott, M. Craig


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